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3 Feb, 26
This IDSA guideline reviews evidence on IV‑to‑oral antibiotic transition in complicated UTI, outlining when clinically improving patients may safely switch to effective oral agents to reduce IV‑related risks, costs, and hospitalization.
3 Feb, 26
3 Feb, 26
BMC Gastroenterol.
- High prevalence of anxiety (26.5%) and depression (12.2%) were seen among gastroenterology outpatients
- Anxiety was associated with reflux, dyspepsia, bile reflux, atrophic gastritis with IM/IN, biliary and liver disease, and poor sleep (adjusted odds ratio, AOR up to 5.58)
- Depression was linked to bile reflux, liver disease and poor sleep (AOR up to 8.57), while ≥150 min/week exercise was protective (AOR 0.550)
2 Feb, 26Cardiovasc Diabetol.
- In 429,740 adults with T2DM (mean age 61.9y, 52.7% men, 75.3% hypertensive), SBP >120–129 mmHg or DBP >70–79 mmHg increased risks of CVD, CKD, kidney failure, & death
- Associations were strongest in ages 18–44, where a 10 mmHg or 1-SD rise in SBP/DBP conferred 1.2–1.5-fold higher hemorrhagic stroke risk (p-interaction<0.001)
- Risk declined with age, underscoring BP control in young T2DM patients.
2 Feb, 26Hypertension.
- In 485 elderly outpatients ≥80y (median age 82, 44.7% male, 89.3% on antihypertensives) followed 3.9y, nocturnal (SBP ≥120, DBP ≥70) vs daytime hypertension was seen in 54.2% & 33.6% patients
- During 1734 person-yrs, 72 CV outcomes ensued (14.8%), nocturnal hypertension predicted events (aHR=2.15), while daytime hypertension showed no association
- Screening for nighttime BP may identify vulnerable elderly patients.
30 Jan, 26Cureus.
- 6 RCTs; N=562
- Azithromycin significantly reduced pulmonary exacerbations in bronchiectasis, yielding standardized mean difference (SMD) –0.63 (p<0.00001) compared to placebo. Benefits were consistent in adults (–1.03) and children (–1.52; p=0.10)
- No significant effects on forced expiratory volume in 1 second (FEV1) or St. George’s respiratory questionnaire (SGRQ) scores
- Adverse events were similar to placebo.
6 Jan, 26
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