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3 Feb, 26
This IDSA guideline outlines evidence‑based empiric and definitive antibiotic selection for complicated UTI, emphasizing severity‑based therapy, resistance risk assessment, patient‑specific factors, and stewardship‑driven narrowing once cultures return.
3 Feb, 26
13 Feb, 26
N Engl J Med
- Streptococcus agalactiae bacteraemia was common in elderly men, especially in the skin and soft tissue & reported a high 30 day mortality rate (9%)
- Time to blood culture positivity (TTP) was shorter in infective endocarditis (IE, 7.5 h vs 9.1 h, p=0.005) but did not differ between survivors & nonsurvivors
- The study suggested a potential role of TTP in identifying patients at IE risk in S. agalactiae bacteraemia.
12 Feb, 26Endocr Pract.
- In 23576 women (24–28 wks gestation) undergoing 75 g OGTT, 7.07% had hypoglycemia (<3.9 mmol/L)
- Hypoglycemic women were younger, had lower BMI & their neonates showed low birth weight (LBW), incidence of larger for gestational age (LGA)/macrosomia was lower & that of LBW & SGA was higher in the neonates born to these women
- Close monitoring in these women is essential to alleviate adverse perinatal outcomes.
11 Feb, 26Diabetes Obes Metab.
- The link between time in target range for BMI (TTR-BMI) was evaluated in a pooled analysis of 9167 adults aged ≥45 y
- A higher TTR-BMI reduced cardiometabolic multimorbidity (CMM), each 1-SD rise in TTR-BMI lowered CMM risk by ~10%, “always in range” (TTR=1) had 23.8% lower CMM risk
- The inverse link was most explicit particularly in those with coexisting diabetes & dyslipidemia (HR 0.76), in men & in those ≥60 y.
11 Feb, 26J Crit Care.
- Fast serum sodium (SNa) correction (>0.5 mmol/L/h) within the first 24 h in critically ill patients with severe hypernatremia reduced 30 day mortality (HR 0.49) and improved 30-day hospital free survival (HR 1.75) vs. slow SNa correction (≤0.5 mmol/L/h)
- It also shortened ICU stay (4 vs 5 days, p = 0.002) and hospital length of stay (8 vs 11 days, p = 0.01)
5 Feb, 26
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