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7 Oct, 26
WHO-recommended Low Osmolarity ORS (LORS) is the standard and most effective solution for managing dehydration in children, reducing stool output, vomiting, and the need for IV fluids. The paper emphasizes improving awareness, accessibility, and adoption of LORS, to ensure consistent use of WHO-compliant formulations.
30 Sep, 26
The guidelines for advanced gastroesophageal cancer emphasize early biomarker testing & personalized use of immunotherapy & targeted therapies, with treatment selection guided by HER2, PD-L1, CLDN18.2, & MSI/MMR status to optimize patient outcomes.
7 Oct, 26
Obesity Facts.
- Analysis of GBD 2023 data showed East Asia had the highest childhood asthma burden attributable to high BMI in 2023 (CDR 16.28/100,000), with the greatest increase since 1990 (EAPC 1.57%/year) & projected growth to 2050 (EAPC 4.49%/year)
- South Asia had the lowest CDR (1.94/100,000)
- CDR correlated positively with SDI (ρ=0.54; P<0.001), with a greater rise among girls.
6 Oct, 26
A 37-year-old man with T1DM and ESKD on peritoneal dialysis had resistant hypertension despite multiple antihypertensives. BP remained uncontrolled despite treatment adjustments. Click here to know how the case was managed.
5 Oct, 26Diabetes Obes Metab.
- In 192 patients with T2DM without overt HF, NT-proBNP levels increased with worsening renal function (204.3 vs 96.8 vs 62.2 pg/mL across eGFR 30-59, 60-89 & ≥90 mL/min/1.73 m²; p<0.001)
- NT-proBNP correlated with albuminuria (uACR; r=0.31, p<0.001) but not FMD (p=0.388)
- Older age (aOR 1.14), higher SBP (aOR 1.05), lower eGFR (aOR 0.97), & beta-blocker use (aOR 4.65) independently predicted elevated NT-proBNP.
29 Sep, 26BMC Infect. Dis.
- Higher albumin-to-glucose ratio (AGR) independently reduced 30-day mortality risk by 18% (adjusted HR 0.82; P<0.001)
- AGR showed good prognostic discrimination with an optimal cutoff of ≥5.0 (AUC 0.713); platelet count mediated only 9.24% of the AGR-mortality association
- Patients with low AGR and low platelet count had a 4.04-fold higher crude mortality risk (HR 4.04; P<0.001)
29 Sep, 26
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