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14 Aug, 26
The ESPID Clinical Practice Guidelines recommend penicillins as first-line treatment for pediatric Group A Streptococcal (iGAS) infections, with the addition of clindamycin for toxin-mediated cases.
14 Aug, 26
Obesity is a chronic, complex disease. Guidelines from the ADA’s Obesity Association, recommend annual screening with BMI, ethnicity-specific diagnostic criteria, waist circumference assessment, & comprehensive staging to guide personalized care.
18 Aug, 26
Diabetes Obes Metab.
- Among 64,404 patients with T2DM, use of SGLT-2 inhibitors, DPP-4 inhibitors, or thiazolidinediones as second-line therapy after metformin was associated with a significantly lower risk of insulin initiation vs insulin secretagogues (HR 0.62, 0.75, and 0.59, respectively)
- Over 2.9 years, SGLT-2 inhibitors also showed greater treatment durability, supporting their use to delay insulin dependence.
18 Aug, 26Epilepsia.
- Among 530 adults evaluated for suspected epilepsy, 30% were diagnosed with epilepsy & 17% had a first unprovoked seizure
- Older adults (65-95 yrs) had a significantly higher relative risk of epilepsy diagnosis vs adults aged 18-64 yrs, independent of sex
- Neuroimaging (97.7%) & EEG (92.6%) utilization were high, with similar diagnostic yield across age grps
- Age-specific assessment may improve 1st-seizure diagnosis.
18 Aug, 26BMC Infect.Dis
- In this meta-analysis of 26,377 patients with gram-negative bacterial infections (GNB), the incidence of bloodstream infection was 17.3%
- The most consistent predictors of bloodstream infection were central venous catheterization, mechanical ventilation, carbapenem use, & immunosuppressive status
- Patients with CR-GNB bloodstream infections were more likely to have hypoalbuminemia & indwelling urinary catheters.
17 Aug, 26Hypertension.
- In ARIC visit 10863 adults (mean age 83.7 yrs) underwent supine & standing BP measurements, initial OH (SBP drop ≥20 mmHg or DBP drop ≥10 mmHg immediately after standing) was seen in 41.3%
- Initial & early OH were linked to orthostatic symptoms (OR 2.34, OR 1.82), while initial OH raised fall rates (RR 1.45)
- BP assessment within 3 mins, especially immediately after standing, best identified clinically relevant OH.
13 Aug, 26
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