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3 Feb, 26
This IDSA guideline outlines evidence‑based empiric and definitive antibiotic selection for complicated UTI, emphasizing severity‑based therapy, resistance risk assessment, patient‑specific factors, and stewardship‑driven narrowing once cultures return.
3 Feb, 26
17 Feb, 26
Diabetes Metab Syndr...
- Systematic review/meta-analysis of 15 studies (12 outcomes) on alpha-lipoic acid (ALA) in diabetic polyneuropathy was conducted
- ALA 600 mg/day improved TSS paresthesia (SMD = −1.04; p<0.00001), numbness (SMD = −0.23; p=0.04) & HPAL (SMD = −1.00; p<0.00001)
- No effect on HbA1c, NO, sural SNAP, peroneal MNCV
- ALA is a safe adjunct for symptom relief but its impact on nerve conduction/glycemic control is inconclusive.
13 Feb, 26N Engl J Med
- Streptococcus agalactiae bacteraemia was common in elderly men, especially in the skin and soft tissue & reported a high 30 day mortality rate (9%)
- Time to blood culture positivity (TTP) was shorter in infective endocarditis (IE, 7.5 h vs 9.1 h, p=0.005) but did not differ between survivors & nonsurvivors
- The study suggested a potential role of TTP in identifying patients at IE risk in S. agalactiae bacteraemia.
12 Feb, 26Endocr Pract.
- In 23576 women (24–28 wks gestation) undergoing 75 g OGTT, 7.07% had hypoglycemia (<3.9 mmol/L)
- Hypoglycemic women were younger, had lower BMI & their neonates showed low birth weight (LBW), incidence of larger for gestational age (LGA)/macrosomia was lower & that of LBW & SGA was higher in the neonates born to these women
- Close monitoring in these women is essential to alleviate adverse perinatal outcomes.
11 Feb, 26J Crit Care.
- Fast serum sodium (SNa) correction (>0.5 mmol/L/h) within the first 24 h in critically ill patients with severe hypernatremia reduced 30 day mortality (HR 0.49) and improved 30-day hospital free survival (HR 1.75) vs. slow SNa correction (≤0.5 mmol/L/h)
- It also shortened ICU stay (4 vs 5 days, p = 0.002) and hospital length of stay (8 vs 11 days, p = 0.01)
5 Feb, 26
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