How often do you see sarcopenia progression influencing treatment decisions in operable HNSCC?
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In patients with operable human papillomavirus (HPV)–negative head and neck squamous cell cancer (HNSCC), sarcopenia trajectories after treatment forecasted poorer survival. Those who had sarcopenia or progressed to sarcopenia had over twice the risk of death (HR 2.08-3.05) and disease-free survival (HR 1.79-2.12) versus consistently non-sarcopenic patients, highlighting sarcopenia’s value as a prognostic biomarker.
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